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The Role of Benchmarking Critical Impurity Control in Therapeutic Oligonucleotide Phosphoramidites
The growing need for oligonucleotide therapeutics aimed at larger patient populations has driven the demand for high-quality nucleoside phosphoramidite which are building blocks for oligonucleotide therapeutics. The global oligonucleotide therapeutics
Mastering and Accelerating sgRNA Synthesis: Unveiling Success Strategies
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Case Study: From Discovery to Phase I, Rapid Delivery of a Complex Peptide Conjugate in 10 Months
Abstract: In the highly competitive peptide market, speed is critical for the success of novel peptide therapeutic development. This case study shows how WuXi TIDES scientists accelerate the development of
Case Study: Fast-Track to Phase I: Two siRNA IND CMC Packages Completed in 14 Months
Abstract: A biotech company engaged WuXi TIDES to develop a siRNA-GalNAc drug candidate for cardiovascular disease. The original synthesis process for this 23-mer siRNA resulted in a yield of 13%
Case Study: An Integrated Solution to Accelerate a Radionuclide Drug Conjugate to IND
In this case study, we demonstrated a project in which the WuXi TIDES peptide team successfully enabled a challenging RDC to IND filing in three months. Leveraging our extensive expertise
Discovery, Characterization and Manufacture of Peptide Radiopharmaceuticals
Overview: A new wave of drugs that achieve the targeted delivery of radioisotopes are rapidly gaining momentum and attracting significant excitement. As the discovery and development pipeline widens, and new
