Unnatural Amino Acid
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Home - Services & Solutions - Peptide - Discovery Synthesis - Unnatural Amino Acid
We are experts in synthesizing a wide variety of unnatural amino acids (UAA), including the most challenging structures, tailored to our customers’ specifications at all stages. We offer 2,500+ unnatural amino acid products with various types and scales.
Visit our UAA Catalog e-Shop here.
Leveraging the knowledge and synthetic expertise of our seasoned chemists, we also offer custom amino acid synthesis services from laboratory scale to production scale. We customized 12,000+ unnatural amino acids in last 5 years.
Experience Highlights
α-Me-amino acids:
- We utilize the natural amino acid Alanine to design α-Me-amino acid derivatives. This methodology can be extended to other natural amino acids, such as Leucine, Phenylalanine, etc.
N-Me-amino acids:
- We have developed a cyclization process that allows methylation to be achieved in just two steps.
PG series:
- All protecting strategies, including Boc, Fmoc, Cbz, Mtt, DDE, and IVDDE, can be implemented.
α- and β- construction series:
- We have developed enzyme catalyst techniques to construct selectable α- or β-site unnatural amino acids.
NCA series:
- We have developed a process to effectively control the quality of NCAs.
Samples of Unnatural Amino Acids
Case Study
- n=0,1,2…, m=1,2,3…
- Custom synthesis, from g to kg scale
- R1, R2, R3 can be different protecting groups upon your design
- Key building block for alternative route in cyclic peptide systhesis
- An alternative option for thioether macrocycles
- Commercial available in small quantity: 100 mg
- Commonly used for copper free click reaction
- Ideal building block for peptide fragment conjugation
- WuXi TIDES is capable of providing these analogs in 500+ grams scale with short timeline.
