End to End CRDMO Platform for
Drugs
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WuXi TIDES oligonucleotide platform provides comprehensive CRDMO services from drug discovery to commercial manufacturing for both drug substance and drug product.
Our oligonucleotide discovery synthesis services support high throughput library synthesis and custom synthesis (nmol-mmol). We cover all types of oligonucleotides, their monomers, linkers, ligands and conjugates. Additionally, we provide dedicated analytical support for all required testing.
We can seamlessly scale up to any scale (mmol – mol) to meet various demands from preclinical, clinical to commercial stages with ample capacities and proven capabilities with commercial success. Beyond chemistry, we provide formulation development and manufacturing services with various dosage forms and filling formats. These services are coupled with comprehensive analytical support for both API and drug product under one quality system, as well as the integrated CMC dossier preparation services, enabling our customers to bring their oligonucleotide therapeutics to market faster.
Oligonucleotide CRDMO Chemistry Platform
from Discovery to Development and Commercial Manufacturing
Oligonucleotide (from nmol to mol)
- DNA | ASO | PMO
- miRNA | siRNA | sgRNA
- Aptamer
Conjugate
- Oligonucleotide-Peptide
- Oligonucleotide-Toxin
- Oligonucleotide-Lipid
- Oligonucleotide-GalNAc
- Peptide-PMO (PPMO)
Services and Solutions
Discovery Synthesis
Development & Manufacturing
Why WuXi TIDES?
![WuXi TIdes Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/WuXi-TIdes.png)
![image 113 Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-113.png)
![image 118 Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-118.png)
![image 116 Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-116.png)
![Global Quality Standard](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/Global-Quality-Standard-img.png)
![image 115 Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-115.png)
![image 114 Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-114.png)
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Scalability
Conjugation Chemistry
Seamless collaboration among oligonucleotide, peptide and small molecule teams
New Technology
Biocatalysis for gRNA Synthesis, Thin Film Evaporation (TFE)
Global Quality Standard
One quality system across all sites approved by major regulatory agencies around the world
Comprehensive Analytical Platform
Method development and validation, IPC and release testing, characterization, stability
Integrated CMC
API Process Development and Manufacturing, Formulation Development and Manufacturing, Analytical, CMC Dossier Preparation and Clinical Supply Services
Meeting global quality standard
![US Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/08/US.png)
15
US FDA Inspections
2013-2024
![EURO Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/08/EURO.png)
7
EU EMA Inspections
2009-2024
![CHINA Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/08/CHINA.png)
53
China NMPA Inspections
2015-2024
![JAPAN Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/08/JAPAN.png)
9
Japan PMDA Inspections
2019-2024
![SOUTH KOREA Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/08/SOUTH-KOREA.png)
4
South Korea MFDS Inspections
![SWITZERLAND Oligonucleotide](https://tides.wuxiapptec.com/wp-content/uploads/2023/08/SWITZERLAND.png)
5
SwissMedic Inspections
2018-2024