Changzhou Site, China
74 acres

Taixing Site, China
168 acres (Phase I: 84 acres)

Our peptide API process development and manufacturing platform provides an end-to-end solution from preclinical to commercial stages. We have built industry-leading capabilities and capacities to support your needs across all development stages, ensuring knowledge retention throughout the product lifecycle. The total reactor volume for Solid Phase Peptide Synthesis (SPPS) is over 32,000 L. 

Comprehensive Peptide Process Development Capability

Our highly experienced peptide development teams, comprised of several hundred scientists, support the process development of various peptide modalities, unnatural amino acid derivatives and complex peptide conjugates from preclinical to commercial production.

 

Our services include, but not limited to:

 

We built a comprehensive process technology tool box to accelerate your peptide development across the product life cycle.

Case Study: Integrated CMC Solution for IND Application in 9 Months​

We supported the 30+ AA macrocyclic peptide project by providing integrated CMC services, including API process development, manufacturing, formulation development, and CMC writing. We successfully completed the IND application within nine months, overcoming the challenges of an original route yield of less than 1% and a limited supply of a special building block for conjugation.

In the end, we developed a new route based on SPPS, and synthesize the main-chain and side-chain in parallel; we further achieved cyclization on resin, and completed the API synthesis via solid phase coupling strategy, which increased the yield by fourfold. The conjugation process was optimized to facilitate Tox and GMP batches in a more efficient manner. In-parallel and seamless workstreams allowed the entire project to be completed in nine months.

Peptide integrated CMC case API

Manufacturing

With our global standard quality system, we are well positioned to be your strategic manufacturing partner for reliable and robust supplies of your peptide APIs, from gram to metric ton scales.

Our custom synthesizers and cleavage systems are designed to minimize risks of both microbial contamination and cross-contamination. Our peptide platform ensures knowledge retention and scale-up throughout your product life cycle, while expediting your development through seamless collaboration among different functional teams.

At our Changzhou and Taixing sites in China, we have over 20 Solid Phase Peptide Synthesis (SPPS) production lines with a wide range of  synthesizers from 20 L to 3,000 L. The total reactor volume for SPPS is over 32,000 L. And we are still expanding our SPPS capacity at Taixing and Singapore sites in the next few years. 

Our peptide manufacturing platform is also equipped with the latest technologies, including Liquid Phase Peptide Synthesis (LPPS), reactor-in-series (with PAT data collection) , continues flow chromatography, Tangential Flow Filtration (TFF) / precipitation, etc.

Liquid Phase Peptide Synthesis (LPPS)
lpps img API
Peptide Conjugate

Peptide conjugation is a rapidly expanding field, serving as a new modality for targeted drug delivery. This technique enhances efficacy and reduces side effects in cancer treatment. Our comprehensive peptide platform, combined with our small molecule chemistry capability, provides peptide conjugate development and manufacturing.

We support various peptide conjugates including but not limited to:

  • Peptide-PMO
  • Peptide-Oligonucleotide
  • Peptide-Toxin
  • Peptide-Metal Complex
  • Radionuclide Drug Conjugate (RDC)
  • Peptide-GalNAc, etc

Our services includes: 

WuXi TIDES peptide 1 API

Samples of 350+ Linkers

w e2 1 03 API
image 340 API
w e2 3 07 API
w e2 4 09 API

Samples of 40+ Payload Modifications

w e2 5 15 API
w e2 6 16 API
w e2 7 17 API
w e2 8 18 API

Case Study: Our Integrated Peptide-toxin Development and Manufacturing Service in 9 months

1659509943777486 API
  • Seamless collaboration with in-parallel activities across 4 workstreams
  • Swift sample transport and information sharing from upstream to downstream teams
Unnatural Amino Acid

We offer over 2,500 catalog products of unnatural amino acid, including backbone modified / side chain modified amino acid and derivative of natural amino acid, etc. We delivered 12,000+ unnatural amino acids in last 5 years.

Visit Amino Acid e-Shop

We are experts in producing unnatural amino acid catalog products, including the most complex structures, tailored to our customers’ specifications from kilo to metric ton scales. Upholding global quality standards, we develop robust processes for amino acid products, ensuring superior quality.

Unnatural Amino Acid
Experience Highlights

α-Me-amino acids:

N-Me-amino acids:

PG series:

α- and β- construction series:

NCA series:

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