Unnatural Amino Acid
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We are experts in synthesizing a wide variety of unnatural amino acids (UAA), including the most challenging structures, tailored to our customers’ specifications at all stages. We offer 2,500+ unnatural amino acid products with various types and scales.
Visit our UAA Catalog e-Shop here.
Leveraging the knowledge and synthetic expertise of our seasoned chemists, we also offer custom amino acid synthesis services from laboratory scale to production scale. We customized 12,000+ unnatural amino acids in last 5 years.
α-Me-amino acids:
- We employ the natural amino acid Alanine to design α-Me-amino acid derivatives. This methodology can be applied to other natural amino acids, such as Leucine, Phenylalanine, and so forth.
N-Me-amino acids:
- We have developed a cyclization process that forms the methylation in just two steps.
PG series:
- All protecting strategies, including Boc, Fmoc, Cbz, Mtt, DDE, and IVDDE, can be applied.
α- and β- construction series:
- We have developed enzyme catalyst techniques to construct selectable α- or β-site unnatural amino acids.
NCA series:
- We have developed a process to effectively control the quality of NCAs.
Samples of Unnatural Amino Acids
![amino 1 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-1-image.png)
![amino 2 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-2-image.png)
![amino 3 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-3-image.png)
![amino 4 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-4-image.png)
![amino 5 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-5-image.png)
![amino 6 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-6-image.png)
![amino 7 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-7-image.png)
![amino 8 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-8-image.png)
![amino 9 image Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/amino-9-image.png)
Case Study
![image 248 Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-248.png)
- n=0,1,2…, m=1,2,3…
- Custom synthesis, from g to kg scale
- R1, R2, R3 can be different protecting groups upon your design
- Key building block for alternative route in cyclic peptide systhesis
- An alternative option for thioether macrocycles
![image 248 1 Unnatural Amino Acid](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-248-1.png)
- Commercial available in small quantity: 100 mg
- Commonly used for copper free click reaction
- Ideal building block for peptide fragment conjugation
- WuXi TIDES is capable of providing these analogs in 500+ grams scale with short timeline.