Peptide Conjugate Discovery

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Peptide conjugation is a rapidly expanding field, offering a new modality for targeted drug delivery. This approach enhances efficacy and reduces side effects in cancer treatment. Our comprehensive peptide platform, combined with our small molecule chemistry capability, provides a one-stop solution for your peptide conjugate discovery projects.

We support various peptide conjugates, including but not limited to:

Peptide-Toxin
Peptide-Metal
Peptide-GalNAc
Peptide-PMO
Peptide-Oligonucleotide
Radionuclide Drug Conjugate (RDC)

Experience Highlights

Samples of 350+ Linkers

Samples of 50+ Payload Modifications

Case Study: Peptide Drug Conjugation

We enabled seamless collaboration among SPPS, LPPS, purification, and analytical teams, all located at one site.

The project was completed 3-4 week faster compared with convension methods of separate manufacturing peptides and payloads.

Seamless collaboration with in-parallel activities among 4 workstreams

Swift sample transport and information sharing from upstream to downstream teams

Case Study: Radionuclide Drug Conjugates (RDC)

In this case study, we demonstrated a project in which the WuXi TIDES peptide teams successfully enabled a challenging RDC to IND filing in three months. Leveraging our extensive expertise and capabilities in peptide and small molecule chemistry, robust synthesis and manufacturing solutions were developed. Download Full Article

Seamless collaboration with in-parallel activities among 4 workstreams

Swift sample transport and information sharing from upstream to downstream teams

Peptide-Phosphorodiamidate Morpholino Oligomers (PMO)

Leveraging our peptide manufacturing from one site in Changzhou, China, WuXi TIDES can also produce peptide-PMO (PPMO) with streamlined process. PMO and PPMO development and manufacturing are supported by our in-house comprehensive analytical, project management, as well as CMC regulatory teams. To date, we have completed dozens of PMO projects including 10+ PPMO projects.

Peptide Oligonucleotide Conjugate (POC)

Our Unique ‘One-Stop’ POC Synthesis Services

‘One-stop’ POC synthesis with 10+ years of experience in both oligonucleotide and peptide
80+ peptides, lipids, PEG linkers — readily available for conjugation chemistry
‘Custom-tailored’ design of linker / conjugation chemistry including dual conjugation chemistry

Learn more about our Oligonucleotide platform.