Peptide Conjugate Discovery
Home | Services & Solutions | Peptide | Discovery Synthesis | Conjugate
![WuXi TIDES peptide 1 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2024/05/WuXi-TIDES_peptide-1.jpg)
Peptide conjugation is a rapidly expanding field, offering a new modality for targeted drug delivery. This approach enhances efficacy and reduces side effects in cancer treatment. Our comprehensive peptide platform, combined with our small molecule chemistry capability, provides a one-stop solution for your peptide conjugate discovery projects.
We support various peptide conjugates, including but not limited to:
- Peptide-Toxin
- Peptide-Metal
- Peptide-GalNAc
- Peptide-PMO
- Peptide-Oligonucleotide
- Radionuclide Drug Conjugate (RDC)
Experience Highlights
- 2,000+ peptide drug conjugate projects delivered
- 350+ linkers synthesized
- 50+ payload modifications completed
- 80+ peptides, lipids, PEG linkers — readily available for conjugation
Samples of 350+ Linkers
![w e2 1 03 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/w_e2_1_03.jpg)
![image 340 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/image-340.jpg)
![w e2 3 07 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/w_e2_3_07.jpg)
![w e2 4 09 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/w_e2_4_09.jpg)
Samples of 40+ Payload Modifications
![w e2 5 15 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/w_e2_5_15.jpg)
![w e2 6 16 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/w_e2_6_16.jpg)
![w e2 7 17 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/w_e2_7_17.jpg)
![w e2 8 18 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/w_e2_8_18.jpg)
![PDC casestudy1 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2024/06/PDC_casestudy1.png)
Case Study: Peptide Drug Conjugation
We enabled seamless collaboration among SPPS, LPPS, purification, and analytical teams, all located at one site.
The project was completed 3-4 week faster compared with convension methods of separate manufacturing peptides and payloads.
![RDC2 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2024/05/RDC2.png)
Case Study: Radionuclide Drug Conjugates (RDC)
In this case study, we demonstrated a project in which the WuXi TIDES peptide teams successfully enabled a challenging RDC to IND filing in three months. Leveraging our extensive expertise and capabilities in peptide and small molecule chemistry, robust synthesis and manufacturing solutions were developed. Download Full Article
Peptide-Phosphorodiamidate Morpholino Oligomers (PMO)
Leveraging our peptide manufacturing from one site in Changzhou, China, WuXi TIDES can also produce peptide-PMO (PPMO) with streamlined process. PMO and PPMO development and manufacturing are supported by our in-house comprehensive analytical, project management, as well as CMC regulatory teams. To date, we have completed dozens of PMO projects including 10+ PPMO projects.
![ppmo img3 Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2024/04/ppmo-img3.png)
Peptide Oligonucleotide Conjugate (POC)
Our Unique ‘One-Stop’ POC Synthesis Services
- ‘One-stop’ POC synthesis with 10+ years of experience in both oligonucleotide and peptide
- 80+ peptides, lipids, PEG linkers in stock — readily available for conjugation chemistry
- ‘Custom-tailored’ design of linker / conjugation chemistry including dual conjugation chemistry
![oligo peptidePOC Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2024/06/oligo-peptidePOC.jpg)
Related Resources
![Challenges and opportunities in Peptide Drug Conjugates PDCs Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/Challenges-and-opportunities-in-Peptide-Drug-Conjugates-PDCs.jpg)
Webinar: Challenges and Opportunities in Peptide Drug Conjugates (PDCs)
![PDC Youchu Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/PDC_Youchu.jpg)
Empowering Highly Potent Peptide Drug Conjugate Scale-up with Flow Chemistry
![PDC casestudy cover Conjugate](https://tides.wuxiapptec.com/wp-content/uploads/2023/10/PDC_casestudy_cover.jpg)