Conjugate
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Oligonucleotide conjugates open up opportunities to deliver the oligonucleotide to a specific cell or tissue and to fine-tune the ‘drug-like’ properties. However, the complexity of conjugation chemistry poses great challenges for drug innovators and manufacturers.
WuXi TIDES is well positioned to provide a one-stop solution for complex oligonucleotide-conjugate drugs from discovery to development and commercial manufacturing, with our strong capabilities in both oligonucleotide, peptide and small molecules including ligand, toxin, linker, lipid, PEG etc.
Why choose WuXi TIDES?
- Comprehensive: Extensive experience in various modalities
- Diversity: Large variety of linkers / conjugation strategies
- Flexibility: Custom-tailored solution according to your application
Type of Oligonucleotide Conjugates
- PPMO
- GalNAc-oligonucleotide
- Lipid-oligonucleotide
- Peptide-oligonucleotide (POC)
- 'Drug'-oligonucleotide
- Dye-labelled oligonucleotide
Linker Chemistry
- Amide Coupling
- Thiol-maleimide addition
- Click chemistry (CuAAC | SPAAC)
- Broad selection of spacers
- Custom-tailored linkers
Topology
- 3'- or 5'-conjugation
- Internal conjugation
- Base/backbone conjugation
- Complex dual conjugation: (3', 5'- / 3', 3'- / 5', 5'-)
- Multi-valency (Mono- / di- / tri- / tetra)
Type of Oligonucleotide Conjugates
- PPMO
- GalNAc-oligonucleotide
- Lipid-oligonucleotide
- Peptide-oligonucleotide (POC)
- 'Drug'-oligonucleotide
- Dye-labelled oligonucleotide
Linker Chemistry
- Amide Coupling
- Thiol-maleimide addition
- Click chemistry (CuAAC | SPAAC)
- Broad selection of spacers
- Custom-tailored linkers
Topology
- 3'- or 5'-conjugation
- Internal conjugation
- Base/backbone conjugation
- Complex dual conjugation: (3', 5'- / 3', 3'- / 5', 5'-)
- Multi-valency (Mono- / di- / tri- / tetra)
Lipid
Peptide
Carbohydrate
Fluorescent-dye
